The Johannesburg-based team are on Tyneside for a 5.30pm kick-off, with Newcastle having started the tournament with a 24-13 triumph away to French club Lyon last Saturday.
The same day saw the Lions beaten 26-18 at home by Italian side Benetton, with Perpignan topping the early pool standings following their 41-17 home win over the Dragons.
Click here to view the table, with the top four teams in each pool going through to the round of 16, where they will be joined by four teams dropping down from the Investec Champions Cup.
Newcastle Red Bulls season ticket holders are reminded that Saturday's game IS included in their 2025-26 package.
Tickets for non-season ticket holders are on general sale by clicking here, with parking available by clicking here.
Elevate your experience with our match-day hospitality. Click here to view our packages and make your booking.